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DeCS
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Descriptor English:
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DNA Damage
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Descriptor Spanish:
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Daņo del ADN
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Descriptor Portuguese:
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Dano ao DNA
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Synonyms English:
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Injury, DNA
DNA Damages
DNA Injuries
Damage, DNA
Damages, DNA
Genotoxic Stresses
Injuries, DNA
Stresses, Genotoxic
DNA Injury
Genotoxic Stress
Stress, Genotoxic
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Tree Number:
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G05.200
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Definition English:
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Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS. |
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Indexing Annotation English:
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do not use /drug eff & /rad eff for DNA damage induced by drugs or radiation; do not confuse with DNA FRAGMENTATION: see note there
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See Related English:
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Mutation
Pyrimidine Dimers
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History Note English:
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87
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Allowable Qualifiers English:
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Record Number:
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19154
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Unique Identifier:
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D004249
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Occurrence in VHL:
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Similar:
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DeCS CID-10 LILACS
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